What are the Implications of Stress Induced Senescence in Tissue Homeostasis?
Stress induced senescence serves as a tumor suppressive mechanism by preventing the proliferation of damaged cells. However, the accumulation of senescent cells in tissues can contribute to tissue dysfunction and age-related diseases. Senescent cells secrete a variety of pro-inflammatory cytokines, growth factors, and proteases, collectively known as the senescence-associated secretory phenotype (SASP), which can affect the microenvironment and promote chronic inflammation.
