What are the Limitations of the Gleason Grading System?
While the Gleason grading system is widely used, it has some limitations: - Subjectivity: Interpretation of histological patterns can vary among pathologists, leading to inter-observer variability. - Sampling Error: A biopsy sample may not capture the most aggressive part of the tumor, potentially underestimating the Gleason score. - Evolution of Cancer: Prostate cancer can evolve over time, and the initial Gleason score may not reflect the current state of the disease.
