- Gleason Pattern 1: This pattern represents well-differentiated prostate cancer cells that closely resemble normal prostate tissue. The glands are small, uniform, and tightly packed. - Gleason Pattern 2: Slightly less differentiated than pattern 1, the glands are still well-formed but are more loosely arranged. - Gleason Pattern 3: Moderately differentiated, the glands are variable in size and shape with infiltration into surrounding tissues. - Gleason Pattern 4: Poorly differentiated, glandular structures are irregular, and there is a significant loss of normal tissue architecture. - Gleason Pattern 5: The least differentiated, with almost no glandular formation and a predominance of solid sheets of cancer cells.
