What are the Limitations of S100 Protein as a Marker?
While S100 protein is a valuable marker, it is not entirely specific. Its expression in a wide variety of cell types means that it can sometimes yield false positives. Therefore, it is often used in combination with other markers to increase diagnostic accuracy. For example, in the diagnosis of melanoma, S100 protein is often used alongside markers like HMB-45 and Melan-A.
