What are the Histological Features of Huntington’s Disease?
Histologically, Huntington’s disease is characterized by significant atrophy in the striatum, including the caudate nucleus and putamen. The cortical regions also show atrophy in advanced stages. Immunohistochemical staining for huntingtin reveals intranuclear and cytoplasmic inclusions, which are hallmark features of the disease. These inclusions are primarily composed of the mutant huntingtin protein and ubiquitin.