What are the Histological Features of Chronic Kidney Disease?
Chronic kidney disease (CKD) is marked by progressive loss of kidney function. Histological examination reveals glomerulosclerosis, tubular atrophy, and interstitial fibrosis. The glomeruli show increased mesangial matrix and basement membrane thickening. Tubular atrophy is characterized by loss of tubular epithelial cells, and interstitial fibrosis involves the excessive deposition of extracellular matrix proteins. These changes can be visualized using specific stains, such as Masson's trichrome.
