How Are Chronic Neurodegenerative Diseases Studied Histologically?
Chronic neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, exhibit unique histological characteristics. In Alzheimer's disease, there is the presence of amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. In Parkinson's disease, the hallmark is the presence of Lewy bodies, which are intraneuronal inclusions containing alpha-synuclein. These histological features can be identified using specific staining methods, such as immunohistochemistry and silver staining.
