How Do Histological Changes Manifest in Chronic Liver Disease?
Chronic liver diseases, including cirrhosis and hepatitis, exhibit distinct histological changes. In cirrhosis, there is extensive fibrosis, leading to the formation of regenerative nodules. Hepatocytes may show signs of ballooning degeneration, and there is often an infiltration of inflammatory cells. The liver architecture is distorted due to the formation of fibrous septa. Special stains like Sirius red can be used to highlight collagen fibers in the liver tissue.
