What are the histological effects of NSAIDs on the kidney?
The kidneys are another site where NSAIDs can exert significant effects. Prostaglandins play a role in maintaining renal blood flow, especially in conditions of reduced blood volume or low blood pressure. Inhibiting COX enzymes with NSAIDs can result in decreased prostaglandin levels, leading to reduced renal blood flow and potential histological changes such as tubular necrosis and interstitial nephritis.
