What Are the Histological Changes Observed in LKB1-Deficient Tissues?
Histologically, tissues deficient in LKB1 often exhibit disrupted cellular architecture, loss of polarity, and increased proliferation. For instance, in the lungs, LKB1 mutations can lead to the formation of benign hamartomas or malignant adenocarcinomas. These changes are characterized by a disorganized cellular structure and increased nuclear atypia.
