What are the Diagnostic and Therapeutic Implications?
From a diagnostic perspective, identifying LKB1 mutations can help in the classification and prognosis of certain cancers. Immunohistochemistry (IHC) and genetic sequencing techniques are commonly used to detect LKB1 status in tissue samples. Therapeutically, understanding the role of LKB1 in cancer can lead to targeted treatments. For example, drugs that activate AMPK or mimic its effects may be beneficial in treating LKB1-deficient tumors.
