What are the Common Issues with Tissue Folding and Stability?
Common issues associated with tissue folding and stability include:
- Tissue Artifacts: Improper folding or stabilization can lead to artifacts, which are misleading structures that do not represent the true tissue architecture. - Shrinkage and Swelling: Chemical fixatives can cause tissues to shrink or swell, affecting their morphology. - Loss of Antigenicity: Over-fixation can lead to the loss of antigenic sites, making it difficult to perform immunohistochemical staining.
