What are the Common Histological Changes in Metabolic Dysfunction?
Several common histological changes are associated with metabolic dysfunction:
1. Cellular Hypertrophy: Enlargement of cells, often seen in cardiomyocytes in response to increased workload. 2. Steatosis: Accumulation of fat within cells, particularly in the liver. 3. Glycogen Accumulation: Excessive storage of glycogen as seen in conditions like glycogen storage diseases. 4. Fibrosis: Excessive formation of connective tissue, which can occur in response to chronic injury, as seen in liver cirrhosis. 5. Cell Death: Both apoptosis and necrosis can be observed in response to severe metabolic stress.
