What are the clinical implications of NHE dysfunction?
Dysfunction or dysregulation of NHE can lead to several clinical conditions. In the kidneys, impaired NHE activity may result in conditions like renal tubular acidosis and hypertension due to disrupted sodium and acid-base homeostasis. In the heart, overactivity of NHE can contribute to pathological cardiac hypertrophy and heart failure by promoting intracellular sodium and calcium overload, leading to cellular injury.
