What are the Clinical Implications of UPS Dysregulation?
Malfunction of the UPS can lead to various diseases: - Cancer: Aberrant degradation of tumor suppressors or oncogenes can promote cancer progression. - Neurodegenerative Diseases: Accumulation of misfolded proteins, as seen in diseases like Alzheimer’s and Parkinson’s, is often linked to UPS impairment. - Cardiovascular Diseases: Proteasome dysfunction is associated with heart failure and other cardiac conditions.
