What are the clinical implications of hippocampal circuitry dysfunction?
Dysfunction in hippocampal circuitry is implicated in several neurological and psychiatric disorders:
1. Alzheimer’s Disease: Characterized by the degeneration of hippocampal neurons, leading to memory loss and cognitive decline. 2. Epilepsy: Abnormal excitatory activity in the hippocampus can result in seizures, particularly in temporal lobe epilepsy. 3. Schizophrenia: Alterations in hippocampal connectivity and function are associated with cognitive deficits and symptoms of schizophrenia.
