How is information processed within the hippocampus?
Information processing within the hippocampus follows a well-defined pathway known as the trisynaptic circuit:
1. Perforant Path: Information from the entorhinal cortex enters the hippocampus via this path and synapses onto granule cells in the dentate gyrus. 2. Mossy Fibers: Granule cells project to the CA3 region via mossy fibers, forming synapses with CA3 pyramidal neurons. 3. Schaffer Collaterals: CA3 pyramidal neurons send their axons to the CA1 region, where they form synapses with CA1 pyramidal neurons. 4. Output: CA1 neurons project to the subiculum and entorhinal cortex, completing the circuit.
