dmt1 (divalent metal transporter 1)

What are the clinical implications of DMT1 dysfunction?

Dysfunction in DMT1 can lead to several clinical conditions. Mutations in the DMT1 gene can cause rare genetic disorders, such as DMT1-associated anemia, characterized by impaired iron uptake and severe microcytic hypochromic anemia. Overexpression or misregulation of DMT1 can contribute to iron overload disorders, such as hemochromatosis, leading to tissue damage and organ failure. Understanding DMT1 function and regulation is therefore essential for developing therapeutic strategies for these conditions.

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