In histology, the expression and localization of DMT1 are crucial for understanding iron metabolism and related disorders. For instance, in the duodenum, DMT1 localization to the apical membrane of enterocytes is essential for iron absorption. In the context of iron overload disorders, such as hemochromatosis, DMT1 expression levels can be altered, leading to excessive iron accumulation in tissues like the liver. Conversely, in conditions like anemia, DMT1 expression can be upregulated to enhance iron uptake.
