Several technologies bridge the gap between histology and genomics:
1. Spatial Transcriptomics: This technique maps gene expression within tissue sections, combining histological imaging with RNA sequencing data. 2. Immunohistochemistry (IHC): IHC uses antibodies to detect specific proteins within tissue sections, correlating protein expression with genetic data. 3. In Situ Hybridization (ISH): ISH localizes specific nucleic acid sequences within tissues, providing spatial context to gene expression. 4. Single-Cell RNA Sequencing (scRNA-seq): This method analyzes gene expression at the single-cell level, allowing for detailed histological correlation.
