What Are the Challenges Associated with Targeting MART-1?
While targeting MART-1 has shown promise, there are challenges such as immune evasion by melanoma cells. Some melanoma cells may reduce or lose expression of MART-1, making them less detectable by T cells. Additionally, there is a risk of autoimmunity since MART-1 is also expressed in normal melanocytes, leading to potential damage to healthy tissues.
