In histological studies, MART-1 can be detected using various techniques such as immunohistochemistry (IHC). IHC involves the use of antibodies that specifically bind to MART-1. These antibodies are often labeled with a colorimetric enzyme or a fluorescent dye, which makes the antigen-antibody complexes visible under a microscope. This allows researchers and clinicians to identify the presence and distribution of melanoma cells in tissue samples.