What Are the Implications of MCADD on Tissue Function?
The accumulation of unmetabolized fatty acids in tissues can lead to cellular dysfunction and tissue damage. In the liver, this can manifest as hepatomegaly and liver failure. In cardiac tissues, it can lead to cardiomyopathy. Skeletal muscle involvement can result in muscle weakness and pain. The brain, when affected, may show signs of hypoglycemic-induced brain injury, which can be severe in young children.
