The primary cellular components involved in bioengineered skin substitutes include:
Keratinocytes: These are the main cell type in the epidermis and are responsible for producing keratin, which provides a protective barrier. Fibroblasts: These cells are found in the dermis and are involved in the synthesis of extracellular matrix components like collagen and elastin. Endothelial Cells: These cells are crucial for forming new blood vessels, a process known as angiogenesis, which is essential for the survival and integration of the skin substitute.
