Skin substitutes are generally classified into three categories based on their composition and structure:
Epidermal Substitutes: These include products like cultured epidermal autografts (CEA), which consist of keratinocytes grown in vitro. Dermal Substitutes: These include acellular dermal matrices (ADM) and dermal regeneration templates, which provide a scaffold for cellular infiltration and tissue regeneration. Composite Substitutes: These combine both epidermal and dermal layers to better replicate the structure and function of natural skin. Examples include Integra® Dermal Regeneration Template and Apligraf®.
