Bioengineered skin substitutes offer several benefits, including reduced healing time, decreased scar formation, and the ability to cover large wound areas. However, there are also challenges that need to be addressed:
Immune Response: The risk of immune rejection is a significant concern, particularly with substitutes that contain allogeneic or xenogeneic components. Vascularization: Ensuring adequate blood supply to the graft is critical for its survival and integration into the host tissue. Mechanical Properties: The substitute must possess mechanical properties that closely mimic those of natural skin to withstand physiological stresses.
