TCGA has led to numerous groundbreaking discoveries, such as:
Molecular Subtypes: Identification of distinct molecular subtypes within cancers, such as the four subtypes of breast cancer: Luminal A, Luminal B, HER2-enriched, and Basal-like. Mutational Signatures: Discovery of specific mutational signatures associated with different carcinogenic processes, aiding in understanding cancer etiology. Therapeutic Targets: Identification of potential therapeutic targets and biomarkers that can guide precision medicine approaches.
