How Does TTF-1 Contribute to Developmental Biology?
TTF-1 plays a pivotal role in the embryonic development of the thyroid gland and lungs. It regulates the expression of genes involved in the differentiation and maturation of cells in these organs. During embryogenesis, TTF-1 expression is necessary for the formation of the thyroid anlage and the branching morphogenesis of the lung. Its absence or malfunction can lead to developmental defects and congenital disorders.
