TCGA samples undergo a rigorous process from collection to data analysis:
Sample Collection: Tissue samples are collected from patients with informed consent, ensuring ethical standards. Histological Examination: Pathologists examine the tissue samples to confirm diagnosis and estimate tumor purity. Genomic Analysis: High-quality samples are subjected to various genomic analyses, including DNA sequencing, RNA sequencing, and epigenomic profiling. Data Integration: Genomic data is integrated with clinical and histological data to create comprehensive cancer profiles.