The expression and activity of DMP1 are regulated by various transcription factors and signaling pathways. For instance, Runx2 and Osterix are key transcription factors that promote DMP1 expression in osteoblasts and osteocytes. Additionally, signaling pathways such as Wnt, TGF-β, and BMP are involved in modulating DMP1 activity, thereby influencing bone and tooth development.
