ATF6 is initially synthesized as a transmembrane protein residing in the ER. Upon accumulation of misfolded proteins, ATF6 translocates to the Golgi apparatus, where it undergoes proteolytic cleavage. This cleavage releases its cytoplasmic domain, which then translocates to the nucleus to act as a transcription factor. In the nucleus, ATF6 induces the expression of genes that enhance the protein folding capacity and degradation of misfolded proteins.
