The proper function of ATF6 is essential for the survival and function of tissues, particularly those with high secretory demands. For instance, in the liver, ATF6 helps in managing the high load of proteins synthesized for secretion into the bloodstream. Similarly, in the pancreas, ATF6 supports the production of digestive enzymes and hormones. Dysfunctional ATF6 can lead to the accumulation of misfolded proteins, potentially causing cell death and contributing to diseases such as diabetes, liver diseases, and neurodegenerative disorders.
