How Does the Extracellular Matrix Affect Tumor Progression?
The extracellular matrix is a dynamic structure composed of various proteins, glycoproteins, and proteoglycans. It provides structural support to tissues and influences cell behavior through biochemical and mechanical signals. In the TME, the ECM undergoes significant remodeling, driven by enzymes such as matrix metalloproteinases (MMPs). This remodeling facilitates tumor cell migration, invasion, and metastasis.
