How is Histological Data Integrated with Genomic Data?
Integration of histological and genomic data in TCGA is achieved through several methodologies: - Image analysis algorithms: These algorithms can quantitatively assess features such as cell density, nuclear shape, and tissue organization. - Correlation studies: Researchers correlate histological features with specific genetic alterations to understand the relationship between morphology and genomics. - Multimodal approaches: Combining histological analysis with other data types (e.g., transcriptomics) to gain a holistic view of tumor biology.
