How do Cancer-Associated Fibroblasts Influence the TME?
Cancer-associated fibroblasts are one of the most abundant components of the TME. These cells secrete a variety of growth factors, such as transforming growth factor-beta (TGF-β) and fibroblast growth factor (FGF), which promote tumor cell proliferation and survival. CAFs also contribute to the remodeling of the ECM, enhancing tumor cell invasion and metastasis.
