How Does Mitochondrial Dysfunction Manifest in Histological Samples?
In histological samples, mitochondrial dysfunction can be identified through various staining techniques and electron microscopy. Common histological markers of mitochondrial dysfunction include altered mitochondrial morphology, such as swollen mitochondria with disrupted cristae, and the presence of mitochondrial inclusions. Additionally, specific stains like succinate dehydrogenase (SDH) and cytochrome c oxidase (COX) can be used to assess mitochondrial enzyme activity.
