How Does Hypergranulosis Relate to Other Histological Changes?
Hypergranulosis is often seen in conjunction with other histological changes such as acanthosis, which is the thickening of the stratum spinosum, and hyperkeratosis, the thickening of the stratum corneum. These changes are indicative of an ongoing reparative or inflammatory process in the skin. In conditions like lichen simplex chronicus, these changes contribute to the clinical presentation of thickened, leathery skin.
