Hypergranulosis is often a response to chronic irritation or inflammation and can be seen in conditions such as lichen planus, psoriasis, and chronic dermatitis. It can also be a result of physical trauma or repetitive friction, as seen in areas of the skin subjected to constant pressure. The increased production of keratinocytes leads to an accumulation of keratohyalin granules, causing the thickening of the granular layer.