How do Postsynaptic Densities Contribute to Synaptic Plasticity?
PSDs contribute to synaptic plasticity through the regulation of receptor composition and signaling pathways. During LTP, there is an increase in the number of AMPA receptors at the postsynaptic membrane, enhancing synaptic strength. Conversely, during LTD, there is a removal of AMPA receptors, leading to synaptic weakening. The dynamic remodeling of PSDs is essential for these processes.
