Structural variations are studied using various histological techniques: - Light Microscopy: This is the most common method, allowing for the observation of tissue organization and cell morphology using staining techniques such as hematoxylin and eosin (H&E). - Electron Microscopy: Provides higher resolution images, enabling the study of ultrastructural details like organelles and the ECM. - Immunohistochemistry: Uses antibodies to detect specific proteins within tissues, helping to identify variations at the molecular level. - Histochemical Staining: Involves staining tissues with specific dyes to highlight different structures, such as Masson's Trichrome for collagen fibers.