How Do Genetic Interactions Contribute to Disease Pathogenesis?
Understanding genetic interactions is key to unraveling the complexities of disease pathogenesis. For instance, in cancer, various oncogenes and tumor suppressor genes interact in intricate ways to drive tumor growth and progression. The p53 gene, a well-known tumor suppressor, interacts with numerous other genes to control cell cycle and apoptosis. Mutations in p53 can disrupt these interactions, leading to uncontrolled cell proliferation and cancer.
