What Histological Changes are Observed in Protein Misfolding Diseases?
Histological changes in protein misfolding diseases often include the presence of intracellular inclusions or extracellular deposits. For example, in Alzheimer's disease, beta-amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein are hallmarks. In Parkinson's disease, Lewy bodies, which are aggregates of alpha-synuclein, are commonly observed. These changes can disrupt normal tissue architecture and lead to cell loss.
