Both ARBs and ACE inhibitors target the renin-angiotensin-aldosterone system but in different ways. ACE inhibitors prevent the formation of angiotensin II by inhibiting the angiotensin-converting enzyme, while ARBs block the effects of angiotensin II at the receptor level. Although both classes of drugs are effective in managing hypertension and heart failure, ARBs are often chosen for patients who experience side effects such as a persistent cough with ACE inhibitors.