How Can Therapeutic Interventions Target Proton Motive Force?
Therapeutic strategies aimed at modulating PMF include:
Antioxidants: These can mitigate ROS damage, preserving PMF and mitochondrial function. Mitochondrial uncouplers: In controlled doses, these can help manage conditions like obesity by dissipating the PMF to generate heat instead of ATP. Gene therapy: Targeting genetic defects in ETC components can restore normal PMF and cellular function.
