What are the Implications of Altered Proton Motive Force in Disease?
Alterations in PMF can have profound implications for cellular and tissue health. In ischemia-reperfusion injury, the sudden restoration of blood flow leads to a surge in reactive oxygen species (ROS), disrupting PMF and causing cell death. Similarly, in mitochondrial myopathies, mutations affecting ETC components impair PMF, leading to muscle weakness and other systemic issues. Understanding these alterations helps in developing targeted therapies to restore normal function.
