Keratinocytes can be studied using various histological techniques. Hematoxylin and eosin (H&E) staining is commonly used to visualize the different layers of the epidermis and the morphology of keratinocytes. Immunohistochemistry can be employed to detect specific proteins such as keratin, providing insights into their functional state. Electron microscopy can reveal the ultrastructure of keratinocytes, including the arrangement of keratin filaments.