1. Barrier Function: They form a physical barrier that protects against environmental hazards such as pathogens, chemicals, and physical trauma. 2. Waterproofing: The keratin and lipids in the stratum corneum prevent water loss, maintaining hydration in the skin. 3. Immune Response: Keratinocytes can produce cytokines and other molecules that participate in the skin's immune response. 4. Wound Healing: They play a role in wound healing by migrating to the site of injury and proliferating to repair the damaged tissue.
