Management of ASC-US depends on the results of follow-up testing:
If HPV testing is negative, the risk of cervical cancer is low, and routine screening can continue. If HPV testing is positive, further evaluation with colposcopy and possible biopsy is necessary to rule out high-grade lesions. Treatment of underlying infections or inflammation may resolve the atypical changes. Regular monitoring and repeat testing ensure that any progression to a more severe condition is caught early and managed appropriately.
