How are Senescent Cells Identified in Histological Studies?
In the context of histology, senescent cells can be identified using several markers. One of the primary markers is senescence-associated β-galactosidase (SA-β-gal), which is detected using a histochemical stain. Other markers include p16^INK4a, p21^CIP1/WAF1, and γ-H2AX. Immunohistochemistry is often used to visualize these markers. Additionally, morphological characteristics such as enlarged cell size and increased granularity can help in identifying senescent cells under the microscope.
