In histological studies, the presence of PSEN2 can be associated with changes in cellular structures. For instance, mutations in PSEN2 can lead to the accumulation of amyloid-beta plaques, which are hallmark features observed in brain tissues affected by Alzheimer's disease. These plaques can be visualized using specific staining techniques and immunohistochemistry, providing a clear link between PSEN2 activity and histopathological findings.
